Development of blood compatible materials by glow discharge-treatment
Identifieur interne : 000181 ( Main/Exploration ); précédent : 000180; suivant : 000182Development of blood compatible materials by glow discharge-treatment
Auteurs : Y. Ishikawa [Japon] ; S. Sasakawa [Japon]Source :
- International Journal of Radiation Applications & Instrumentation. Part C, Radiation Physics & Chemistry [ 1359-0197 ] ; 1992.
Abstract
Glow discharge-treatment was applied to preparation of blood compatible materials.Plasticized polyvinylchloride (PVC) which is used for blood bags was treated in the presence of various gases or monomers. Wettability of PVC was modified by the treatment over a wide range. And leakage of plasticizer, di-(2-ethylhexyl)phthalate (DEHP), was prevented. When platelet concentrates were stored in the treated PVC bags, impairment of platelet functions was suppressed by the prevention of DEHP leakage. But platelet adhesion to the surfaces increased by the treatments.Aldehyde groups were grafted on polyethylene film (PE) by glow discharge-treatment in the presence of formaldehyde gas. Although the aldehyde-grafted PE (HCHO-PE) had higher reactivity with platelet than PE after albumin coating, it exhibited excellent antithrombogenicity after blood plasma coating. HCHO-PE adsorbed proteins with almost the same composition as blood plasma, although non-treated PE adsorbed proteins with higher fibinogen/albumin ratio. Segmented-polyurethane which is well known to exhibit good antithrombogenicity, also formed the adsorption layer having composition like that of blood plasma. These results suggest that protein layer adsorbed with blood plasma composition is hardly recognized by platelets. Glow discharge-treatment is a simple and effective method for surface modification of medical polymers.
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DOI: 10.1016/1359-0197(92)90113-T
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Ishikawa</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Research, Central Blood Center, The Japanese Red Cross Society, 1-31, Hiroo, 4-chome, Shibuya-ku, Tokyo 150</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Sasakawa, S" sort="Sasakawa, S" uniqKey="Sasakawa S" first="S." last="Sasakawa">S. Sasakawa</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Research, Central Blood Center, The Japanese Red Cross Society, 1-31, Hiroo, 4-chome, Shibuya-ku, Tokyo 150</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">International Journal of Radiation Applications & Instrumentation. Part C, Radiation Physics & Chemistry</title><title level="j" type="abbrev">IJRAIC</title><idno type="ISSN">1359-0197</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1992">1992</date><biblScope unit="volume">39</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="561">561</biblScope><biblScope unit="page" to="567">567</biblScope></imprint><idno type="ISSN">1359-0197</idno></series><idno type="istex">B9224D484FEEE0ECA7887BC32662E643E0840B82</idno><idno type="DOI">10.1016/1359-0197(92)90113-T</idno><idno type="PII">1359-0197(92)90113-T</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1359-0197</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Glow discharge-treatment was applied to preparation of blood compatible materials.Plasticized polyvinylchloride (PVC) which is used for blood bags was treated in the presence of various gases or monomers. Wettability of PVC was modified by the treatment over a wide range. And leakage of plasticizer, di-(2-ethylhexyl)phthalate (DEHP), was prevented. When platelet concentrates were stored in the treated PVC bags, impairment of platelet functions was suppressed by the prevention of DEHP leakage. But platelet adhesion to the surfaces increased by the treatments.Aldehyde groups were grafted on polyethylene film (PE) by glow discharge-treatment in the presence of formaldehyde gas. Although the aldehyde-grafted PE (HCHO-PE) had higher reactivity with platelet than PE after albumin coating, it exhibited excellent antithrombogenicity after blood plasma coating. HCHO-PE adsorbed proteins with almost the same composition as blood plasma, although non-treated PE adsorbed proteins with higher fibinogen/albumin ratio. Segmented-polyurethane which is well known to exhibit good antithrombogenicity, also formed the adsorption layer having composition like that of blood plasma. These results suggest that protein layer adsorbed with blood plasma composition is hardly recognized by platelets. Glow discharge-treatment is a simple and effective method for surface modification of medical polymers.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement></list><tree><country name="Japon"><region name="Région de Kantō"><name sortKey="Ishikawa, Y" sort="Ishikawa, Y" uniqKey="Ishikawa Y" first="Y." last="Ishikawa">Y. Ishikawa</name></region><name sortKey="Sasakawa, S" sort="Sasakawa, S" uniqKey="Sasakawa S" first="S." last="Sasakawa">S. Sasakawa</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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